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Antibody-based molecular recognition plays a dominant role in the life sciences ranging from applications in diagnostics and molecular imaging to targeted drug delivery and therapy. Here we report a generic approach to introduce protease sensitivity into antibody-based targeting by taking advantage of the intrinsic ability of antibodies to engage in multivalent interactions.
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Wouter Engelen, Lenny H. H. Meijer, Bram Somers, Tom F. A. de Greef & Maarten Merkx. Authors. Wouter Engelen. View author publications. You can also search for this author in PubMed.
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Freek V. de Graaf, Stef A. H. Jansen, Tobias Schnitzer, E. W. Meijer, Ghislaine Vantomme. Controlling Helical Asymmetry in Supramolecular Copolymers by In Situ Chemical Modification. Journal of the American Chemical Society 2023 , 145 (26) , 14379-14386.
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Authors Tom F A De Greef 1 , Maarten M J Smulders , Martin Wolffs , Albert P H J Schenning , Rint P Sijbesma , E W Meijer Affiliation 1 Institute for Complex Molecular Systems and Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. PMID: 19769364
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Numerous biological applications, from diagnostic assays to immunotherapies, rely on the use of antibody-conjugates. The efficacy of these conjugates can be significantly influenced by the site at which Immunoglobulin G (IgG) is modified. Current methods that provide control over the conjugation site, however, suffer from a number of shortfalls and often require large investments of time and.
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Johan De Greef graduated in 2000 as a MSc in Bioscience Engineering with a major in process and environmental technology. He obtained a PhD in Chemical Engineering on the subject of flow and mass transfer in structured catalytic reactor systems.
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Martijn de Greef's 43 research works with 789 citations and 5,000 reads, including: Thermal ablation of a confluent lesion in the porcine kidney with a clinically available MR-HIFU system
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A computer made of DNA
A photocrosslinkable protein G variant was used as an adapter protein to covalently and site-specifically conjugate an antibody and an Fc-fusion protein to an oligonucleotide. This modular approach enables straightforward decoration of DNA nanostructures with complex native proteins while retaining their inn 2017 Emerging Investigators
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Pathway complexity in supramolecular polymerization. 2012 Jan 18;481 (7382):492-6. doi: 10.1038/nature10720. Self-assembly provides an attractive route to functional organic materials, with properties and hence performance depending sensitively on the organization of the molecular building blocks. Molecular organization is a direct consequence.
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Tom F. A. de Greef Dr. Laboratory of Macromolecular and Organic Chemistry and Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven (The Netherlands), Fax: (+31) 40-245-1036. Maarten M. J. Smulders. Laboratory of Macromolecular and Organic Chemistry and Institute for Complex Molecular.
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Maarten De Graef Ghent University | UGhent ยท Department of Electrical Energy, Systems and Automation Connect with experts in your field Join ResearchGate to contact this researcher and connect.
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Sara A Galle 1 2 , Jan Berend Deijen 3 4 , Maarten V Milders 3 , Mathieu H G De Greef 5 , Erik J A Scherder 3 , Cornelia M van Duijn # 6 7 8 , Madeleine L Drent # 3 9 Affiliations 1 Department of Clinical, Neuro- and Developmental Psychology, Vrije Universiteit Amsterdam, Van Der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. s.a.galle.
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27 Nov 2020 Vol 370, Issue 6520 pp. 1034 - 1035 DOI: 10.1126/science.abb5607 Cytokines have far-reaching effects on the behavior of immune cells. Given their powerful roles, there has been a long history of trying to harness cytokines as therapeutic drugs for cancer and other diseases.